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Endocrine Abstracts

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ea0090p423 | Pituitary and Neuroendocrinology | ECE2023

Immune profile in acromegalic patients and the impact of the current medical treatment. Resultsfrom the PROMISE study

Feola Tiziana , De Alcubierre Dario , Sada Valentina , Puliani Giulia , Sciarra Francesca , Cozzolino Alessia , Appetecchia Marialuisa , Sbardella Emilia , Jaffrain-Rea Marie-Lise , Anna Venneri Mary , Isidori Andrea

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...
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ea0099p318 | Pituitary and Neuroendocrinology | ECE2024

Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-levels analysis from a multicenter clinical trial

Hasenmajer Valeria , Sbardella Emilia , Sciarra Francesca , Rizzo Flavio , Simeoli Chiara , Pivonello Claudia , Pivonello Rosario , Ceccato Filippo , Scaroni Carla , Arnaldi Giorgio , Pofi Riccardo , Cozzolino Alessia , Minnetti Marianna , Alunni Fegatelli Danilo , Conia Simone , Navigli Roberto , Gianfrilli Daniele , Anna Venneri Mary , Isidori Andrea

Background: Glucocorticoids (GC) are potent entrainers of the circadian clock, however their effect on biological rhythms in human chronic exposure have been poorly studied. Endogenous hypercortisolism (Cushing’s Syndrome, CS) is a rare condition, in which circadian disruption is sustained by a tumorous source of GC excess, offering the unique opportunity to investigate the in vivo chronic effects of GC.Methods: In a 12-month prospective mu...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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